Conversion From Hypothyroidism to Hyperthyroidism and Back After Anti-SARS-CoV-2 Vaccination

Cases presenting with changes in various organs caused by anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are rare. In particular, after such instances of vaccination, onset subacute thyroiditis, Hashimoto and Graves’ disease was observed. We present the case a 55-year-old woman whose hypothyroidism converted to hyperthyroidism Gam-COVID-Vac (Sputnik V). After first dose vaccine, hormonal metabolism alteration noted, i.e., conversion from euthyroidism. second thyrotoxicosis noted without signs thyroiditis. Hyperthyroidism persisted for several weeks before reverting hypothyroidism. Assessments did not reveal an increase patient’s thyroid-stimulating hormone receptor antibody levels throughout indicated period. However, reverted hypothyroidism, significant peak systolic velocity superior thyroid arteries observed, which is characteristic hyperthyroidism. Owing known involvement autonomic nervous system (ANS) blood vessel tone regulation, hormonogenesis, stress, ANS-mediated certain individuals receiving may serve as sufficient stimulus ANS nerve centers, highly probable. Therefore, diagnostic assessment condition should be performed patients chronic disorders or diseases other organ systems. If found, providing preemptive treatment recommended. J Endocrinol Metab. 2022;12(6):202-208 doi: https://doi.org/10.14740/jem833